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Figure 2 | Molecular Pain

Figure 2

From: Oxytocin-induced antinociception in the spinal cord is mediated by a subpopulation of glutamatergic neurons in lamina I-II which amplify GABAergic inhibition

Figure 2

Differential effects of a selective oxytocin receptor (TGOT) on glutamatergic and GABAergic synaptic currents. A: Raw recordings of spontaneous AMPA-R sEPSCs (left traces) illustrate the increase of frequency triggered by the application of TGOT (1 μM). This effect was reversible and observed in 35.7% of the lamina II neurons. Histograms on the right show the mean increase (± SEM) in frequency (with respect to control) of sEPSCs and mEPSCs. B: Elevation in the frequency of occurrence of GABAA-R sIPSCs was observed in all lamina II neurons recorded (n = 6 out of 6; raw traces and histogram on the left). However, TGOT never changed the frequency of miniature GABAA-R events (right histogram). Asterisks indicate statistical significance using Student's t-test, p < 0.05.

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Molecular Pain

ISSN: 1744-8069

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