Table 2 Voltage-dependence of activation and steady-state inactivation of the TTX-R and TTX-S Na+ currents in the slow and fast small-sized control, CCD and CCI DRGs.
| Â | TTX-R Current | TTX-S Current | ||||||
|---|---|---|---|---|---|---|---|---|
| Â | V1/2act (mV) | k act | V1/2inact (mV) | k inact | V1/2act (mV) | k act | V1/2inact (mV) | k inact |
Slow Neurons | ||||||||
   Control | -17.9 ± 1.1 (14) | 4.3 ± 0.3 (14) | -35.3 ± 0.7 (14) | -4.0 ± 0.1 (14) | -26.6 ± 1.3 (14) | 5.6 ± 1.1 (14) | -77.6 ± 2.2 (14) | -8.0 ± 0.5 (14) |
   CCD | -18.7 ± 1.7 (15) | 4.9 ± 0.4 (15) | -38.8 ± 0.8** (12) | -4.6 ± 0.2* (12) | -26.2 ± 1.4 (15) | 5.2 ± 0.6 (15) | -84.0 ± 1.3* (12) | -9.9 ± 0.5* (12) |
   CCI | -15.6 ± 1.6 (7) | 5.1 ± 0.5 (7) | -38.1 ± 0.7* (7) | -4.6 ± 0.1* (7) | -26.1 ± 1.4 (7) | 4.0 ± 0.8 (7) | -75.1 ± 5.1 (7) | -12.4 ± 1.8** (7) |
Fast Neurons | ||||||||
   Control | -13.0 ± 1.2 (13) | 5.6 ± 0.4 (13) | -39.4 ± 1.1 (14) | -4.4 ± 0.1 (14) | -26.2 ± 1.4 (13) | 4.9 ± 0.6 (13) | -84.4 ± 1.9 (14) | -8.9 ± 0.4 (14) |
   CCD | -14.3 ± 1.7 (9) | 5.8 ± 0.7 (9) | -37.9 ± 1.3 (7) | -5.3 ± 0.2** (7) | -23.0 ± 1.8 (9) | 5.6 ± 1.1 (9) | -75.7 ± 1.5* (7) | -9.4 ± 0.8 (7) |
   CCI | -12.0 ± 0.8 (12) | 5.9 ± 0.4 (12) | -36.8 ± 1.1 (10) | -5.0 ± 0.2* (10) | -26.8 ± 1.2 (12) | 5.4 ± 1.1 (12) | -80.4 ± 2.8 (10) | -10.1 ± 0.8 (10) |