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Figure 1 | Molecular Pain

Figure 1

From: Hemispheric lateralization of a molecular signal for pain modulation in the amygdala

Figure 1

Effects of intra-amygdala U0126 infusion on formalin-induced mechanical hypersensitivity. Five days after cannulation, animals were injected with 5% formalin into the right (a, c) or the left (b, d) hind-paw. Two hours after the paw injection, mice were infused into the right (a, b) or the left (c, d) amygdala with the MEK inhibitor U0126 (n = 6 animals), the structural analog control compound U0124 (n = 6 animals) or vehicle (n = 5–6 animals). One hour after the amygdala injection, the effects of these treatments on mechanical thresholds were analyzed. U0126 infusion into the right amygdala significantly reduced formalin-induced primary hypersensitivity and eliminated secondary hypersensitivity, independent of the side of paw injection (p < 0.05, One-way ANOVA, Tukey's post-test; * = p < 0.05, *** = p < 0.0001) (a, b). U0126 infusion into the left amygdala did not significantly affect formalin-induced mechanical hypersensitivity (c, d). Data displayed in panel A was obtained with permission from Carrasquillo and Gereau, J Neurosci. 2007 Feb 14;27 (7): 1543–51.

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