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Figure 4 | Molecular Pain

Figure 4

From: PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior

Figure 4

An ERK inhibitor (U0126) inhibits synaptic plasticity but not normal synaptic transmission. Monosynaptic EPSCs were evoked at the PB-CeLC and BLA-CeLC synapses in slices from normal (A, C) and arthritic (6 h postinduction; B, D) rats. U0126 (1 μM, 15 min) inhibited synaptic transmission in neurons from arthritic rats 6 h postinduction (D, n = 6; P < 0.05, paired t-test) but not in control neurons (C, n = 6). (A, B) Original recordings of EPSCs (average of 8–10 trials) evoked at the two synapses. (C, D) Averaged EPSC amplitudes (mean ± SE) in the presence of U0126 normalized to predrug control values (set to 100%). Whole-cell voltage-clamp recordings were made at -60 mV. * P < 0.05.

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