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Figure 7 | Molecular Pain

Figure 7

From: PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior

Figure 7

A PKC inhibitor (GF109203X) has no effect on synaptic transmission. Monosynaptic EPSCs were evoked at the PB-CeLC and BLA-CeLC synapses in slices from normal (A, C) and arthritic (6 h postinduction; B, D) rats. GF109203X (1 μM, 15 min) had no significant effect (P > 0.05, paired t-test) in neurons from arthritic rats (n = 6) and in control neurons from normal rats (n = 5). (A, B) Original recordings of EPSCs evoked at the two synapses (average of 8–10 EPSCs). (C, D) Averaged EPSC amplitudes (mean ± SE) in the presence of GF109203X normalized to predrug control values (set to 100%).

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Molecular Pain

ISSN: 1744-8069

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