Figure 5
From: Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1
Intraplantar injection of 15d-PGJ 2 causes acute nociceptive responses via TRPA1. (A) 10 μL of vehicle (10% DMSO in saline) or 15 nmol 15d-PGJ2 was injected into the hindpaw of C57BL/6J mice (n = 5 per group) and nociceptive behaviors (licking and lifting of the paw) for 10 minutes. 15d-PGJ2 caused significant nociceptive responses compared to vehicle. (B) 15d-PGJ2-induced nociceptive behaviors are absent in TRPA1 knockout mice (n = 5 per group). ***p < 0.001