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Figure 1 | Molecular Pain

Figure 1

From: Intracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain

Figure 1

Effects of intracerebroventricular (ICV) injection of 10 μg of ZJ43 (a), 2-PMPA (b) or NAAG (c) on the time course of the flinches observed after the formalin injection into the dorsal surface of the right rat hind-paw. Drugs were administered 10 min before the formalin injection. The group II mGluR antagonist LY341495 (1mg/kg, i.p.) was injected 10 min before ZJ43, 2-PMPA, NAAG or saline (d). The number of flinches/min is plotted vs time after the formalin injection. NAAG and the NAAG peptidase inhibitors ZJ43 and 2-PMPA significantly reduced both phases of the response to formalin injection (see text for statistical assessment). The effects of the peptidase inhibitors were blocked by the LY341495 as was the effect of NAAG on phase 2 of the response to formalin. Each line represents the group mean and S.E.M. of four to six rats.

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Molecular Pain

ISSN: 1744-8069

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