Skip to main content
Figure 9 | Molecular Pain

Figure 9

From: Descending serotonergic controls regulate inflammation-induced mechanical sensitivity and methyl-CpG-binding protein 2 phosphorylation in the rat superficial dorsal horn

Figure 9

5,7-DHT attenuates mechanical sensitivity but not thermal sensitivity. Seven days after 5,7-DHT or saline treatment, animals received CFA in the hind paw. A/ 5,7-DHT did not change the increased thermal sensitivity seen after CFA injection in the hind paw as measured by the Hargreaves test. N = 5/6.B/ 5,7-DHT significantly attenuated the inflammation-induced decrease in mechanical threshold measured by the automatic Von Frey from 1 h after CFA injection. The response was still attenuated 24 h later. N = 7/8. For A, and B, data show mean ± standard error of the mean; *P < 0.05, **P < 0.001.

Back to article page

Molecular Pain

ISSN: 1744-8069

Contact us