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Figure 4 | Molecular Pain

Figure 4

From: The role of cation-dependent chloride transporters in neuropathic pain following spinal cord injury

Figure 4

Changes in NKCC1 and KCC2 expression in non-hyperalgesic and hyperalgesic rats. NKCC1 protein expression in the injury epicenter spinal cord tissues at 21, 28, 35, and 42 days post-SCI. Sham (S) samples were acquired from animals subject to laminectomies without subsequent spinal cord contusion. Top panel, the blot was probed with anti-NKCC1 antibody and anti-GFAP (glial fibrillary acidic protein) antibody. Lower panel, the blot was probed with anti-KCC2 antibody and anti-GFAP antibody. Hyperalgesic rats (labeled as pain) were identified with the thermal hyperalgesia withdrawal latency test as described above. (+): hyperalgesia; (-): without hyperalgesia. n = 2.

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