Figure 4
From: Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable
Effect of prepulse duration on voltage-dependence of inactivation. A, Comparison of steady-state fast-inactivation for WT (squares, n = 3) and M1627K (circles, n = 4) Nav1.7 channels. Currents were elicited with test pulses to 0 mV following either 100 ms (filled symbols) or 500 ms (unfilled symbols) inactivating prepulses. The apparent voltage-dependence of inactivation of WT Nav1.7 channels is altered by the prepulse duration. In contrast the apparent voltage-dependence of inactivation of M1627K mutant channels is not significantly altered by changing the prepulse duration from 100 to 500 ms. Data are presented as mean ± S.E.