Figure 7
From: Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable
M1627K mutant channels increase frequency of firing of DRG neurons compared to WT Na v 1.7 channels. The mean total number of action potentials (defined as spikes in membrane potential greater than 0 mV) for a current injection pulse of 1 second duration is plotted as a function of stimulus current intensity. The responses of neurons expressing M1627K mutant channels (n = 31) was significantly elevated over the responses of neurons expressing WT Nav1.7r channels (n = 28) for stimulus current injections exceeding 200 pA (p < 0.05).