Figure 9
From: Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable
Representative traces illustrating the differences in action potential firing in DRG neurons expressing either WT or M1627K channels. The upper panels are the responses of a DRG neuron expressing M1627K channels in which the threshold for action potential generation was 25 pA. Panel A: stimulus intensity was 50 pA (2× threshold); panel B: stimulus intensity was 75 pA (3× threshold); panel C: stimulus was 350 pA (14× threshold) at which the peak rate was recorded. The lower panels are the responses of a DRG neuron expressing WT Nav1.7 channels in which the threshold for action potential generation was 450 pA. Panel D: stimulus intensity was 900 pA (2× threshold); panel E: stimulus was 1400 pA (3× threshold); panel F: shows that the peak response for this cell occurred at 1200 pA.