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Figure 2 | Molecular Pain

Figure 2

From: The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons

Figure 2

Overnight incubation with GRO/KC (1.5 nM) increases Na+ current density. A. TTX-R current density significantly increased in IB4-negative cells after GRO/KC incubation. P < 0.0001 for overall effect. Individual voltages at which the difference between control and GRO/KC treated cells was significant are indicated by the * symbol (two-way RM ANOVA with Holm-Sidak method for Pairwise Multiple Comparisons). B. A similar but smaller enhancement of TTX-R current was observed in IB4-positive cells (overall p value = 0.0016). TTX-S current density measured at -30 to -10 mV as described in methods, also significantly increased after GRO/KC incubation in both IB4-negative (C; and IB4-positive cells (D). Data are from 9 cultures; N = 53 control cells and 54 GRO/KC treated cells.

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Molecular Pain

ISSN: 1744-8069

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