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Figure 3 | Molecular Pain

Figure 3

From: Differential regulation of morphine antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice

Figure 3

Laser evoked CSD profiles across cortical layers of the S1 in WT and KO mice. (A) Schematic diagram of the recording scheme. The position of the multichannel probe is overlaid with histological sections from the S1. Cortical layers are indicated by roman numerals. Arrow indicates the electrolytic lesion mark in layer V. (B) CSD sweeps across the cortical layers in WT (left panel) and KO (right panel) mice. Gray lines indicate the averaged CSD sweeps from individual mice. Black lines indicated the grand averaged CSD sweeps from WT (n = 18) and KO (n = 16) mice. Sink currents are in the downward direction and source currents are in the upward direction. Sink 1a (early component) and sink 2a and sink 2b (late components) were identified. All of the evoked CSD profile was evoked by laser stimuli with intensity of 10 W and duration of 20 ms. (C) Percent of maximal amplitude change of sink 2a evoked by increment of laser duration.

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