Figure 5

Electrical evoked CSD profiles across cortical layers of the ACC in WT and KO mice. (A) Schematic diagram of the recording scheme and the electrical stimulation parameters: 10 mA, 0.5 ms duration and 0.1 Hz. The position of the multichannel probe is overlaid with histological sections of the ACC. Cortical layers are indicated by roman numerals. Arrow indicates the electrolytic lesion mark in layer V. (B) CSD sweeps across the cortical layers in WT (left panel) and KO (right panel) mice. Gray lines indicate averaged CSD sweeps from individual mice. Black lines indicate the grand averaged CSD sweeps from WT (n = 4) and KO (n = 4) mice. Sink 1, sink 2 and sink 3 were identified. (C) Percent of maximal amplitude change of sink 2 evoked by increment of electrical intensity of stimulus.