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Figure 1 | Molecular Pain

Figure 1

From: Distinct expression of synaptic NR2A and NR2B in the central nervous system and impaired morphine tolerance and physical dependence in mice deficient in postsynaptic density-93 protein

Figure 1

Expression of NR2A and NR2B in total soluble (A) and synaptosomal membrane (B) fractions from dorsal horn, forebrain cortex, and cerebellum in wild type (WT) and PSD-93 knockout (KO) mice. (A) Top: representative Western blots showing the levels of PSD-93, NR2A, and NR2B in the total soluble fraction. Bottom: statistical summary of the densitometric analysis expressed relative to the corresponding loading control (β-actin). (B) Top: representative Western blots showing the amounts of PSD-93, NR2A, and NR2B in the synaptosomal membrane fraction. Bottom: statistical summary of the densitometric analysis expressed relative to the corresponding loading control (N-cadherin). **P < 0.01 vs the corresponding naïve WT mice.

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