Figure 4
From: Sumatriptan inhibits synaptic transmission in the rat midbrain periaqueductal grey
5-HT inhibition of evoked IPSCs is largely mediated by 5-HT1B receptors. Bar chart displaying the mean reduction in evoked IPSC amplitude produced by 5-HT (1 μM) in neurons which were either not pre-incubated in any antagonist (control), or were pre-incubated in the 5-HT1A antagonist WAY100135 (3 μM), the 5-HT1B antagonist NAS181 (10 μM), or the 5-HT1D antagonist BRL15572 (10 μM). Evoked IPSC amplitude is expressed as a percentage of the pre-5-HT level. **, ## denote p < 0.01, 0.0001.