Skip to main content
Figure 7 | Molecular Pain

Figure 7

From: Sumatriptan inhibits synaptic transmission in the rat midbrain periaqueductal grey

Figure 7

5-HT inhibits evoked EPSCs in PAG neurons. (A) Time course of evoked EPSC amplitude (eEPSC Ampl) during application of 5-HT (10 μM) and sumatriptan (3 μM). (B) Averaged evoked EPSCs before (control) and during application of 5-HT and sumatriptan. (C) Bar chart showing the amplitude of the first evoked EPSC (eEPSC1) and the ratio of evoked EPSC2/EPSC1 (eEPSC2:1) in the presence of 5-HT (10 μM) and sumatriptan (3 μM), expressed as a percentage of the pre-drug level. In (C) * and ## denote p < 0.05 and 0.0001. Traces in (A – B) are from the same neuron.

Back to article page