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Figure 5 | Molecular Pain

Figure 5

From: Mechanisms involved in an increment of multimodal excitability of medullary and upper cervical dorsal horn neurons following cutaneous capsaicin treatment

Figure 5

pERK-LI cells in Vc after graded heat stimulus of the lateral facial skin in rats with capsaicin or vehicle application to the skin. A-F: Photomicrographs of Vc following 40, 45 and 50°C stimuli of the face in vehicle- (A-C) or capsaicin-treated rats (D-F). G-L: Rostro-caudal distribution of pERK-LI cells in Vc and C1-C2 following graded heat stimulus of the skin in vehicle- (G-I) and capsaicin-treated rats (J-L). M: Mean number of pERK-LI cells in Vc and C1-C2 following graded heat stimulation of the skin in vehicle- (open columns) and capsaicin-treated (solid columns) rats. N: Mean number of pERK-LI cells in Vc and C1-C2 after heating (50°C) of the skin in rats receiving MEK inhibitor PD98059 or vehicle i.t. injection. *: p < 0.05, **: p < 0.01, $: p < 0.05 (Veh + heat vs. Cap + heat), $$: p < 0.01 (Veh + heat vs. Cap + heat), #: p < 0.05 (Cap + heat vs. Cap), ##: p < 0.01 (Cap + heat vs. Cap). Veh: vehicle for capsaicin, Cap: capsaicin, PD: PD98059, Veh for PD: vehicle for PD98059.

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Molecular Pain

ISSN: 1744-8069

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