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Figure 3 | Molecular Pain

Figure 3

From: Targeted mutation of EphB1 receptor prevents development of neuropathic hyperalgesia and physical dependence on morphine in mice

Figure 3

EphrinB1-Fc-induced changes of thermal sensitivity in EphB1-/- , EphB1+/- and EphB+/+ mice. A: EphrinB1-Fc (1 μg)-induced thermal hypersensitivity in WT mice is prevented by NMDA receptor antagonist MK-801 (5 μg, pretreated). Injection of IgG-Fc (1 μg) did not change the thermal sensitivity, nor did MK-801 alone affect the responses. B: EphrinB1-Fc (1 μg) induced thermal hypersensitivity in EphB1+/+, but not in EphB1+/- and EphB1-/- mice. The values of thermal withdrawal are mean values of both feet. The numbers of mice in each group are shown in parentheses. The arrow indicates drug injection (i.t.) at the time point. **P < 0.01 indicate significant differences between groups of the different treatments and the PBS control.

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Molecular Pain

ISSN: 1744-8069

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