Skip to main content
Figure 4 | Molecular Pain

Figure 4

From: Targeted mutation of EphB1 receptor prevents development of neuropathic hyperalgesia and physical dependence on morphine in mice

Figure 4

Alteration of excitability of medium-sized DRG neurons from EphB1-/- , EphB1+/- and EphB+/+ mice. A, Examples of neural responses recorded intracellularly during the test sequence used to determine AP threshold. Only one of the depolarizing 50-ms pulses (bottom) and corresponding responses (top) are illustrated in each case. B, Examples of neural discharge patterns evoked by depolarizing current. Alterations of the RMP, AP threshold current and repetitive discharge are summarized in C, D and E, respectively. The numbers of cells tested in each group are shown in parentheses. *P < 0.05, **P < 0.01 indicate significant differences compared with the group of sham EphB1+/+. ##P < 0.01 indicate the significant differences compared with the group of CCI-treated EphB1+/+.

Back to article page

Molecular Pain

ISSN: 1744-8069

Contact us