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Table 1 Thermal hyperalgesia in wide type and EphB1 receptor knockout or knockdown mice after nerve injury (CCI treatment) and intrathecal administration of ephrinB1-Fc.

From: Targeted mutation of EphB1 receptor prevents development of neuropathic hyperalgesia and physical dependence on morphine in mice

Group

Total mice

Number of mice (%)

  

with hyperalgesia

without hyperalgesia

CCI treatment

   

   EphB1+/+

12

11 (91.7%)

1 (8.3%)

   EphB1-/-

12

1 (8.3%)

11 (91.7%)

   EphB1+/-

11

1 (9.1%)

10 (90.9%)

EphrinB1-Fc (1 μg, i.t)

   

   EphB1+/+

10

10 (100%)

0

   EphB1-/-

10

0

10 (100%)

   EphB1+/-

12

2 (16.67%)

10 (83.33%)

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Molecular Pain

ISSN: 1744-8069

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