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Figure 2 | Molecular Pain

Figure 2

From: Origins, actions and dynamic expression patterns of the neuropeptide VGF in rat peripheral and central sensory neurones following peripheral nerve injury

Figure 2

Increased VGF protein expression in L4/5 DRG following SNI. A. VGF protein immunostaining in naive L4 DRG shows very low basal levels compared to B. 7 days following SNI where a significant increase in the expression of VGF in all diameter cell bodies can be seen. Inset shows detail of punctuate cytoplasmic VGF staining. C. The mean number of cells/section expressing VGF in the ipsilateral and contralateral L4 DRG, 21 days post SNI highlights this increase in ipsilateral labeling for VGF (* p ≤ 0.05, t-test, n = 3 per group). D. Retrograde labelling of injured cell bodies (red) shows VGF expression is largely found in both large and small injured cell bodies (orange, arrows), although expression is also visible in uninjured/untraced DRG cell bodies (arrow). Scale bars 50 μm.

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Molecular Pain

ISSN: 1744-8069

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