Skip to main content
Figure 5 | Molecular Pain

Figure 5

From: Origins, actions and dynamic expression patterns of the neuropeptide VGF in rat peripheral and central sensory neurones following peripheral nerve injury

Figure 5

TLQP-62 alters the spontaneous excitability of superficial dorsal horn neurones. sEPSCs were recorded in lamina I and II neurones from P21 spinal cord slices using whole cell patch clamp techniques. Cells were clearly divided in their response to TLQP-62 (50 nM) with 6/9 neurones showing a significant increase in the frequency of sEPSCs while 3/9 cells were significantly inhibited, as illustrated by sample traces (A) and histograms showing the normalised frequency of spontaneous activity before and 10 minutes after TLQP-62 application (B). The effects were classified as inhibitory or excitatory using a Komologorov-Smirnov 2-sample test (P < 0.05) and a t-test was used to compare the population data in B (*P < 0.05).

Back to article page