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Table 1 Effects of IL-1β on Resting Membrane Potential (RMP) and Rheobase in five electrophysiologically defined neuron types in organotypic cultures of rat spinal cord.

From: Long-term actions of interleukin-1β on delay and tonic firing neurons in rat superficial dorsal horn and their relevance to central sensitization

 

Tonic

Delay

Irregular

Transient

Phasic

RMP (mV)

-52.5 ± 2.6

-48.6 ± 5.9

-51.3 ± 1.8

-45.0 ± 5.2

-56.3 ± 4.1

BSA Controls

n = 11

n = 5

n = 23

n = 5

n = 4

RMP (mV)

-53.2 ± 4.6

-54.6 ± 3.7

-53.6 ± 1.9

-45.0 ± 5.4

-44.0 ± 4.6

100 pM IL-1β

n = 6

n = 8

n = 14

n = 4

n = 3

Rheobase (pA)

25.0 ± 2.0

61.0 ± 20.0

82.5 ± 12.1

135.0 ± 32.9

118.8 ± 53.2

BSA Controls

n = 9

n = 5

n = 18

n = 4

n = 4

Rheobase (pA)

31.7 ± 10.1

72.1 ± 8.4

70.8 ± 11.9

173.8 ± 65.9

105.0 ± 20.0

100 pM IL-1β

n = 6

n = 7

n = 12

n = 4

n = 2

  1. Data expressed as Means ± SE. p values ranged from 0.12 to 0.99