Table 3 Pharmacological observations.
SNP | Genotype | Morphine dose mg/24 h median [range] | P value | Allele carriage | Morphine dose mg/24 h Median [range] | P value |
|---|---|---|---|---|---|---|
Rs2075507 | AA | 90 [20–420] | 0.220 | A | 80 [20–760] | 0.90 |
AG | 70 [20-480] | Not A | 60 [10–660] | |||
GG | 60 [10–660] | G | 70 [10–760] | 0.09 | ||
Not G | 90 [20–420] | |||||
Rs737866 | AA | 70 [10–660] | 0.486 | A | 73 [10–760] | 0.26 |
AG | 80 [20–760] | Not A | 90 [20–350] | |||
GG | 90 [20–350] | G | 80 [20–760] | 0.45 | ||
Not G | 70 [10–660] | |||||
Rs7287550 | CC | 70 [20–760] | 0.862 | C | 78 [10–760] | 0.59 |
CT | 80 [10–410] | Not C | 120 [30–420] | |||
TT | 120 [30–420] | T | 80 [10–420] | 0.91 | ||
Not T | 70 [20–760] | |||||
Rs5746849 | GG | 115 [20–420] | 0.103 | G | 80 [20–420] | 0.57 |
GA | 80 [20–390] | Not G | 65 [10–760] | |||
AA | 65 [10–760] | A | 70 [10–760] | 0.03c | ||
Not A | 115 [20–420] | |||||
Rs740603 | AA | 70 [10–760] | 0.099 | A | 70 [10–760] | 0.04c |
AG | 80 [20–390] | Not A | 110 [20–420] | |||
GG | 110 [20–420] | G | 80 [20–420] | 0.92 | ||
Not G | 70 [10–760] | |||||
Rs6269 | AA | 70 [20–660] | 0.090 | A | 70 [10–660] | 0.03c |
AG | 75 [10–480] | Not A | 120 [20–760] | |||
GG | 120 [20–760] | G | 80 [10–760] | 0.32 | ||
Not G | 70 [20–660] | |||||
Rs2239393 | AA | 70 [20–660] | 0.093 | A | 70 [10–660] | 0.03c |
AG | 73 [10–480] | Not A | 120 [20–760] | |||
GG | 120 [20–760] | G | 80 [10–760] | 0.42 | ||
Not G | 70 [20–660] | |||||
Rs4818 | CC | 60 [10–660] | 0.042 a | C | 70 [10–660] | 0.04c |
CG | 80 [20–480] | Not C | 120 [20–760] | |||
GG | 120 [20–760] | G | 80 [20–760] | 0.04c | ||
Not G | 60 [10–660] | |||||
Rs4680 (Val158Met) | GG | 90 [20–760] | 0.022 b | G | 80 [10–760] | 0.045c |
GA | 80 [10–480] | Not G | 60 [20–660] | |||
AA | 60 [20–660] | A | 70 [10–660] | 0.07 | ||
Not A | 90 [20–760] | |||||
Rs174699 | CT | 80 [20–480] | 0.666 | C | 80 [20–480] | 0.67 |
Not C | 73 [10–760] | |||||
TT | 73 [10–760] | T | 80 [10–760] | - | ||
Not T | - | |||||
Rs165728 | CT | 80 [20–480] | 0.457 | C | 80 [20–480] | 0.46 |
Not C | 70 [10–760] | |||||
TT | 70 [10–760] | T | 80 [10–760] | - | ||
Not T | - |