Table 4 Pharmacological observations I % II
a – Pharmacological observations I. Morphine dose and haplotype groups | |||||
|---|---|---|---|---|---|
Haplotype | Carriage | N | Morphine dose mg/24 h median [range] | P value | |
1 | Yes | 114 | 60 [10–660] | 0.006 a | |
No | 83 | 100 [20–760] | |||
2 | Yes | 61 | 80 [20–410] | 0.94 | |
No | 136 | 70 [10–760] | |||
3 | Yes | 31 | 90 [20–420] | 0.44 | |
No | 166 | 78 [10–760] | |||
4 | Yes | 24 | 70 [20–420] | 0.94 | |
No | 173 | 80 [10–760] | |||
5 | Yes | 17 | 120 [20–760] | 0.17 | |
No | 180 | 78 [10–660] | |||
6 | Yes | 17 | 120 [30–200] | 0.56 | |
No | 180 | 73 [10–760] | |||
7 | Yes | 10 | 120 [40–290] | 0.44 | |
No | 187 | 80 [10–760] | |||
N = number of patients a Mann-Whitney U test for independent samples. | |||||
b – Pharmacological observations II. Serum concentration of morphine, M6G and M3G against haplotype groups | |||||
Haplotype | Carriage | N | Morphine (nmol/ml) median [range] | M6G (nmol/ml) median [range] | M3G (nmol/ml) median [range] |
1 | Yes | 114 | 51 [2–350] | 310 [10–2660] | 1810 [120–16200] |
No | 83 | 59 [3–1070] | 349 [20–4830] | 2310 [110–21250] | |
2 | Yes | 61 | 50 [3–330] | 346 [20–2482] | 1890 [120–12390] |
No | 136 | 60 [2–1070] | 319 [10–4830] | 2040 [110–21250] | |
3 | Yes | 31 | 67 [5–320] | 310 [29–1690] | 2200 [197–7780] |
No | 166 | 50 [2–1070] | 330 [10–4830] | 1992 [110–21250] | |
4 | Yes | 24 | 51 [3–277] | 380 [20–2482] | 2213 [110–12390] |
No | 173 | 57 [2–1070] | 320 [10–4830] | 1992 [120–21250] | |
5 | Yes | 17 | 80 [4–1070] | 403 [20–4830] | 2415 [110–21250] |
No | 180 | 52 [2–519] | 325 [10–2660] | 1960 [120–16200] | |
6 | Yes | 17 | 90 [9–230] | 470 [120–1105] | 3118 [1017–5481] |
No | 180 | 50 [2–1070] | 318 [10–4830] | 1890 [110–21250] | |
7 | Yes | 10 | 50 [6–220] | 460 [81–1809] | 1832 [490–9460] |
No | 187 | 58 [2–1070] | 330 [10–4830] | 2020 [110–21250] | |