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Table 5 Patient symptoms.

From: Genetic variation in the Catechol-O-Methyltransferase (COMT) gene and morphine requirements in cancer patients with pain

 

Haplotype 1

P value a

 

Carriers

Non-carriers

 

BPI average pain

3.5 (2.6)

3.9 (2.2)

0.26

Fatigue (EORTC score)

64.5 (23.5)

68.6 (23.1)

0.28

Nausea and vomiting (EORTC score)

26.6 (25.9)

27.0 (28.5)

0.77

Dyspnea (EORTC score)

36.6 (32.5)

34.4 (34.7)

0.80

Sleep (EORTC score)

35.3 (36.0)

32.8 (35.2)

0.58

Appetite (EORTC score)

53.2 (37.6)

54.3 (37.2)

0.95

Constipation (EORTC score)

54.5 (37.9)

55.7 (38.4)

0.77

Mini mental examination sum score

26.1 (3.4)

25.6 (4.0)

0.66

  1. a Mann-Whitney U test for 2 independent samples
  2. Patient symptoms for carriers and non-carriers of haplotype 1.