Figure 2
From: Altered ATP release and metabolism in dorsal root ganglia of neuropathic rats
Altered ATP release from DRG after SNE injury. A: ATP release from naive rat DRG is increased by KCl (100 mM) stimulation. * denotes p < 0.05 compared with basal ATP levels. Basal release was defined as the average of 4 samples obtained 1 min prior to onset of KCl stimulation. For clarity, samples 1–9 are not shown. B: Basal ATP release is higher than in naive DRG, whereas KCl stimulation no longer evokes ATP release from ipsilateral DRG. C: The pattern of ATP release from contralateral DRG is similar to naive DRG. * denotes p < 0.05 compared with basal ATP level. D: Summary graph of basal and evoked ATP release in DRG from naive and SNE neuropathic rats. Data were binned as illustrated in A-C. Note the increased basal and loss of KCl-evoked ATP release in ganglia ipsilateral to the SNE.