Figure 4

Selective A1 receptor blockade increases basal ATP levels and relieves the blockade of KCl-evoked ATP release in DRG ipsilateral to SNE. A: Data are presented as mean ± SEM of sample ATP concentration from L4/L5 DRG contralateral to SNE before and after KCl (100 mM) application. B: Data from DRG contralateral to SNE during continuous presence of DPCPX (30 nM). C: Data from DRG ipsilateral to SNE before and after KCl (100 mM) application. Note the absence of KCl-evoked ATP release. D: Data from DRG ipsilateral to SNE during continuous presence of DPCPX (30 nM). E: Summary graph of basal and evoked ATP release in DRG from neuropathic rats in the presence and absence of DPCPX. Data were binned as illustrated in A-D. Note the DPCPX-induced increases in basal release and recovery of KCl-evoked release of ATP in DRG ipsilateral to SNE.