Figure 5

Mechanical allodynia after incision as affected by morphine and pentoxifylline. In these experiments mice were subjected to nociceptive testing of the hind paw to establish the baseline threshold. Mice were then pre-treated with either saline or morphine for 4 days prior to hind paw incisions being made. After incision, groups of mice were treated daily with daily intraperitoneal saline or pentoxifylline as described in Methods. Nociceptive testing 72 hours after hind paw incision (2 hours after the last dose of pentoxifylline). **p < 0.01, N = 8/group.