Histopathology of rat pancreas at week 10. A. Naïve animals were fed low soy chow and given no treatment. B. Method control animals given the alcohol and high-fat diet to induce pancreatitis were given pancreatic injection of vehicle (DMEM) only. C. Some animals with alcohol and high-fat diet induced pancreatitis were given pancreatic HSV-β-gal applications, serving as the vector control. Note the steatosis, inflammatory cell infiltration, acinar cell necrosis, tissue edema, ductal widening and periductal fibrosis seen in the controls, with alcohol and high-fat diet induced pancreatitis given vehicle or the HSV-β-gal applications (B and C). D. Greatly reduced inflammatory cell infiltration and preservation of pancreatic tissue architecture was seen in animals fed the alcohol and high-fat diet but treated with the HSV-ENK vector. The histopathology of the HSV-ENK vector-treated animals was similar to that of the naïve animals (A). Hemotoxylin and eosin (H&E) stain.