met-Enkephalin immunohistochemical staining in thoracic DRG. Photomicrographs of immunohistochemical staining for met-enkephalin in DRG (T7–9) of (A) naïve and control animals (B, C) with alcohol and high-fat diet induced pancreatitis at week 10. Minimal staining is typical of peptides in the absence of axonal transport inhibitors since they are rapidly transported to axonal terminals. D. Note the increased met-ENK staining in DRG of animals with HSV-ENK treatment fed the alcohol and high-fat diet, compared to the naïve and control animals. Intracellular staining appears primarily in small and medium sized cells of the T7–T9 DRG of the HSV-ENK treated animals.