Figure 3

Changes in blood glucose level, body weight and thermal pain sensitivity in TRPV1 knock-out mice (B6.129S4-Trpv1^{tm 1Jul}/J) injected with STZ. A. After intraperitoneal injection of STZ, within the first week, blood glucose level significantly increased (filled squares, n = 14, p < 0.001) and remained constant throughout the course of the experiment as compared to non-diabetic TRPV1 knock-out mice (open squares, n = 6) or the background strain of TRPV1 knock-out mice (C57BL/6J) (open circles n = 15). B. The body weight of TRPV1 knock-out diabetic mice remained constant (filled squares, n = 14), but the body weight of non-diabetic knock-out mice increased steadily (open squares, n = 6, p < 0.001). C. PWL of TRPV1 knock-out diabetic mice, determined every week did not show any significant change (filled squares, n = 14) as compared to control non-diabetic TRPV1 knock-out mice (open squares, n = 6) and the background strain of TRPV1 knock-out mice (open circles n = 15). Note that PWL is significantly higher in TRPV1 knock-out mice as compared to the background strain. Asterisk (**) represents p < 0.001.