Figure 11

Tetrodotoxin (TTX)-resistant sodium currents in lumbar DRG neurons. A, Representative TTX-R current traces in ASIC3^+/+ mice. The TTX-R currents mediated by Nav1.8 (I_Nav1.8) were induced by membrane depolarization from -80 to -40 mV; TTX-R currents of I_Nav1.9 were induced membrane depolarization from -80 to -60 mV. B, Representative TTX-R current traces in ASIC3^-/- mice. C, Mean peak amplitudes of TTX-R currents in ASIC3^+/+ mice. D, Mean peak amplitudes of TTX-R currents in ASIC3^-/- mice. The number of experiments (n) is indicated above each bar. **P < 0.01.