Figure 6
From: Role of acid-sensing ion channel 3 in sub-acute-phase inflammation
CFA-inflamed muscle. Representative H&E sections obtained 2 days after induced inflammation. A, Normal control muscle section. B, CFA-inflamed ASIC3+/+ muscle. Myocytes were separated and rounded up with leukocytes migrated into the intercellular space. Lipid drops surrounded by mononuclear cells were seen. C, CFA-inflamed ASIC3-/- muscle. D, A higher magnitude picture taken from CFA-inflamed ASIC3+/+ muscle. Black arrow shows a myocyte being invaded by mononuclear cells. White arrow indicates the centralized nucleus in a myocyte. E, Well-formed granulomas (black arrow) in CFA-inflamed ASIC3+/+ muscle. F, An ill-defined granuloma (black arrow) in CFA-inflamed ASIC3-/- muscle.