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Figure 1 | Molecular Pain

Figure 1

From: Peripheral nerve injury sensitizes neonatal dorsal horn neurons to tumor necrosis factor-α

Figure 1

TNFα incubation strengthens excitatory synaptic efficacy in the immature SDH under neuropathic conditions. (A) Example of mEPSCs observed at a holding potential (hp) of -70 mV in a neonatal SDH neuron. (B) Incubation of spinal cord slices with TNFα (1 ng/ml) significantly increased mEPSC frequency in P9-11 SDH neurons after SNI at P6 (right; *p < 0.05 compared to SNI+Vehicle; two-way ANOVA) but not in sham-operated littermates (left). (C) Similarly, TNFα significantly increased mEPSC amplitude in SDH neurons after SNI (right; **p < 0.01 compared to SNI+Vehicle; two-way ANOVA) but not following sham operations (left). The SNI alone did not significantly affect mEPSC frequency (B) or amplitude (C).

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