Skip to main content
Figure 3 | Molecular Pain

Figure 3

From: Peripheral nerve injury sensitizes neonatal dorsal horn neurons to tumor necrosis factor-α

Figure 3

Acute application of TNFα fails to strengthen excitatory synapses in the neonatal SDH following SNI. (A) Representative traces illustrating mEPSCs in a P10 SDH neuron before (top) and 5 minutes after (bottom) the bath application of TNFα (1 ng/ml). Continued perfusion of the slice with TNFα for a period of up to 10 min failed to facilitate excitatory synaptic transmission in the dorsal horn. (B) The acute application of TNFα did not significantly alter the mean frequency (left) of mEPSCs recorded in P9-11 SDH neurons following SNI at P6, and produced a significant decrease in mEPSC amplitude (right; *p = 0.024; Wilcoxon matched pairs test) in the same neurons, suggesting that prolonged exposure to TNFα is required for the potentiation of glutamatergic synaptic efficacy in the injured SDH.

Back to article page