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Figure 5 | Molecular Pain

Figure 5

From: Peripheral nerve injury sensitizes neonatal dorsal horn neurons to tumor necrosis factor-α

Figure 5

TNFα decreases the paired-pulse ratio of evoked EPSCs in immature SDH neurons under neuropathic conditions. (A) Representative traces of monosynaptic EPSCs evoked by paired focal stimulation at a variety of interstimulus intervals (ISI) from a holding potential of -70 mV. Each trace represents the average of 10 evoked EPSCs. (B) Incubation with TNFα significantly decreased the paired-pulse ratio (PPR) across the range of ISI examined (p = 0.007; two-way ANOVA).

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