Figure 1

COMT expression is downregulated by TNFα in primary astrocytes. Administration of TNFα (20 ng/ml) decreases COMT protein expression in primary astrocytes as indicated by (A) a representative Western blot and (B) quantitative analysis of Western blots from experiments performed in triplicate. (C) Administration of TNFα (20 ng/ml) also decreases MB-COMT mRNA expression in primary astrocytes. Data are Means ± SEM. *P < 0.05 and **P < 0.01 different from untreated control.