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Figure 1 | Molecular Pain

Figure 1

From: High concentrations of morphine sensitize and activate mouse dorsal root ganglia via TRPV1 and TRPA1 receptors

Figure 1

Morphine activates TRPV1 and TRPA1 expressed in HEK cells. HEK cells transfected with cDNA for hTRPV1 and mTRPA1 were exposed to 10 mM morphine. The upper traces show an inward current in a cell transfected by hTRPV1 and GFP, evoked by 10 mM morphine and by 300 nM capsaicin, both applied for a period of 10 s. The lower traces show an inward current in a cell transfected by mTRPA1 and GFP, evoked by 10 mM morphine and by 30 μM mustard oil, both applied for a period of 40 s. Cells were exposed to 1 μM m-3M3FBS before application of morphine and between applications.

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Molecular Pain

ISSN: 1744-8069

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