Figure 4From: Behavioural and electrophysiological characterisation of experimentally induced osteoarthritis and neuropathy in C57Bl/6 mice Behavioural nociception in PSNL mice. A. Development of mechanical hypersensitivity in PSNL mice. Graph depicts the changes in mechanical force required to elicit a paw withdrawal in response to a mechanical stimulus for the ipsilateral and contralateral hindpaws of PSNL mice (n = 11) and the ipsilateral hindpaws of sham mice (n = 11). 50% paw withdrawal thresholds (PWT) are expressed as mean ± S.E.M. B. Development of thermal hypersensitivity in PSNL mice. Graph depicts the time taken to elicit paw withdrawal in response to a noxious thermal stimulus for the ipsilateral and contralateral hindpaws of PSNL mice (n = 11) and the ipsilateral hindpaws of sham mice (n = 11). * denotes significant differences of ipsilateral PSNL v ipsilateral sham; denotes significant differences of PSNL ipsilateral v PSNL contralateral. 3 symbols, p < 0.001; 2 symbols, p < 0.01; 1 symbol, p < 0.05.Back to article page