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Figure 1 | Molecular Pain

Figure 1

From: Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors

Figure 1

HC-030031 inhibits formalin response but not capsaicin response in rat C fibers. A) An example of a C fiber from rat responding to formalin (0.010%) and then capsaicin (10 μM) after a 10 min incubation of the receptive field with either vehicle (1% DMSO; top; conduction velocity: 0.394 m/s; von Frey threshold: 14.6 mN) or HC-030031 (100 μM; bottom; conduction velocity: 0.298 m/s; von Frey threshold: 20.1 mN). Action potential waveform is shown at the right of each trace. A 4 min washout was given between the formalin and capsaicin tests, and the receptive field was treated with either vehicle or HC-030031 during the washout period. B) Percentage of total C fibers responding to formalin after a 10 min treatment with vehicle or HC-030031 (100 μM; p = 0.05; Fisher's exact test). C) The average formalin-evoked action potentials over 2 min after 10 min treatment with vehicle or HC-030031. D) Percentage of total C fibers responding to capsaicin after a 10 min treatment with vehicle or HC-030031 (100 μM; p > 0.05; Fisher's exact test). E) The mean capsaicin-evoked action potentials over 2 min after 10 min treatment with vehicle or HC-030031 (p > 0.05; Student's t-test).

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