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Figure 2 | Molecular Pain

Figure 2

From: Antidepressants inhibit P2X4 receptor function: a possible involvement in neuropathic pain relief

Figure 2

Effect of antidepressants on ATP-evoked [Ca2+ ] i response via human P2X 4 receptors. Effect of pretreatment of cells with antidepressants (10 μM, 10 min) on the ATP-evoked [Ca2+]i response via human P2X4 receptors (a). Paroxetine dose-dependently inhibited the ATP-evoked [Ca2+]i response via human P2X4 receptors with an IC50 value of 1.87 μM for 30 μM ATP stimulation (b). ATP dose-response curve was generated in the presence of increasing concentrations of paroxetine (c). Data are means ± SEM of at least 3 cells (a, b and c).

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