Figure 3
From: Antidepressants inhibit P2X4 receptor function: a possible involvement in neuropathic pain relief
Effect of antidepressants on ATP-evoked currents in 1321N1 cells expressing rat P2X 4 receptors and primary microglia. Paroxetine (10 μM, 10 min) inhibited ATP (30 μM, 10 sec) evoked currents in rat P2X4 receptor-expressed 1321N1 cells (a and b) and primary micloglia (c and d) (***p < 0.001; paroxetine vs. vehicle, unpaired t-test). Data are means ± SEM of more than three separate experiments.