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Figure 2 | Molecular Pain

Figure 2

From: NR2B receptor blockade inhibits pain-related sensitization of amygdala neurons

Figure 2

Time course of the effects of arthritis and Ro-256981 in an individual amygdala neuron. The responses of the CeA neuron to innocuous (500 g/30 mm2) and noxious (2000 g/30 mm2) stimulation of the knee (A) and background activity (B) increased after induction of the knee joint arthritis Administration of Ro-256981 (1, 10, and 100 μM; concentration in the microdialysis probe; 15 min) into the CeA reduced the enhanced responses (A) but not background activity (B) in a concentration-dependent fashion. Symbols show the mean activity during a 15 s period before stimulation (= background activity, B) and the difference between mean activity during and before 15 s stimuli (= net activity evoked by noxious or innocuous stimuli, A). Artificial cerebrospinal fluid (ACSF) was administered as a vehicle control before and after drug application.

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