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Figure 1 | Molecular Pain

Figure 1

From: Activation of cytosolic phospholipase A2 in dorsal root ganglion neurons by Ca2+/calmodulin-dependent protein kinase II after peripheral nerve injury

Figure 1

A MEK inhibitor U0126 does not prevent cPLA 2 activation after nerve injury. (A) Effect of U0126 on the development of nerve injury-induced tactile allodynia. Results are means ± SEM of the paw withdrawal thresholds on the ipsilateral (ipsi) and contralateral (contra) sides. **p < 0.01, ***p < 0.001 compared with the threshold on day 0. ###p < 0.001 compared with the threshold of the vehicle-treated group. (B, C) Immunohistochemical (B) and western blot (C) analyses of p-ERK and p-cPLA2 proteins in the ipsilateral L5 DRG of vehicle- and U0126-treated rats 7 days after nerve injury. Scale bar, 50 μm.

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Molecular Pain

ISSN: 1744-8069

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