Figure 1
From: Intrathecal delivery of PDGF produces tactile allodynia through its receptors in spinal microglia
A single intrathecal PDGF-BB administration produces tactile allodynia. The paw withdrawal thresholds in response to mechanical stimuli were measured in rats intrathecally administered vehicle (n = 5) or PDGF-BB (0.1, 1 and 10 pmol, n = 5) just before administration (day 0) and 1, 2, 3, 5, 7, 10, and 14 days after administration. Data represent the means ± SEM of the thresholds. ***P < 0.001, **P < 0.01, *P < 0.05 vs vehicle group by repeated measures two-way ANOVA with Bonferroni post-hoc tests.