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Figure 4 | Molecular Pain

Figure 4

From: Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation

Figure 4

Effects of MKP-1 and/or MKP-3 inhibition on p-ERK1/2. (A) Representative western blots of p-ERK1/2 and beta-actin in primary microglia treated with LPS and JWH015 (15 min incubation, JWH). Cells were pre-incubated with or without 10 μM PSI2106 (PS), Ro-31-8220 (Ro) or triptolide (Trip) for 30 min. (B) Triptolide increased the expression of p-ERK1/2 in parallel with the inhibition of both MKP-1 and MKP-3. C. PSI2106 or Ro-31-8220 did not modify p-ERK1/2 expression. *p < 0.05 vs. LPS + JWH015.

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Molecular Pain

ISSN: 1744-8069

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