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Figure 6 | Molecular Pain

Figure 6

From: Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation

Figure 6

Quantification of JWH015-reduced LPS-stimulated microglial migration. (A) JWH015 reduced the number of LPS-stimulated microglia that migrated towards ADP in a dose related fashion. *p < 0.05 vs. medium control group (0) group. (B) Blockade of the effects of JWH015 (1 μM,) on microglial migration by the selective CBR2 antagonist, AM630, but not by the selective CBR1 antagonist, AM281. Data are presented as the number of cells that migrated towards ADP. +p < 0.05 vs. medium group (MED), *p < 0.05 vs. JWH015 1 μM group (JWH) group. (C) Blockade of microglial migration by the selective MEK inhibitor UO126 in LPS-stimulated microglia. UO126 (1 μM), which selectively blocked MEK and thereby ERK phosphorylation, significantly reduced the number of LPS-stimulated microglia that migrated towards ADP. *p < 0.05 vs.medium group (MED) group.

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